Effect of NSAIDS on Post-Exercise Protein Synthesis

How many of you tend to take ibuprofen, aspirin, or any other NSAIDS (Non-Steroidal-Anti-Inflammatory-Drugs) to alleviate the soreness that ensues after a grueling workout? As we all know, sometimes you are sore (even more-so) 2-3 days after the workout; hence the term Delayed Onset Muscular Soreness (DOMS). It is well documented in the scientific literature that NSAIDS can safely and effectively reduce the pain associated with DOMS. Personal fitness trainers everywhere recommend that their clients use them, especially beginners who will tend to get sorer in the initial stages of their fitness program. Unfortunately, taking NSAIDs after a workout not only reduces our perception of pain, but also post-exercise muscle protein synthesis. What this means in lay men’s terms is that if we take NSAIDs the day of and during the days after an intense workout, we are short-circuiting the growth process! Research has conclusively proven this from vitro studies of myocytes in culture, in vivo animal studies, and even in exercising humans. While you may feel better after a tough weight workout or intense cardio session if you take a few Advil, think twice because over the long term this could significantly hinder your progress! If you currently employ a fitness trainer who recommends the use of NSAIDs post-workout, feel free to refer him to this post, or better yet our new column at Pinnacle Fitness:
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